Shaping the learning curve: epigenetic dynamics in neural plasticity
نویسندگان
چکیده
A key characteristic of learning and neural plasticity is state-dependent acquisition dynamics reflected by the non-linear learning curve that links increase in learning with practice. Here we propose that the manner by which epigenetic states of individual cells change during learning contributes to the shape of the neural and behavioral learning curve. We base our suggestion on recent studies showing that epigenetic mechanisms such as DNA methylation, histone acetylation, and RNA-mediated gene regulation are intimately involved in the establishment and maintenance of long-term neural plasticity, reflecting specific learning-histories and influencing future learning. Our model, which is the first to suggest a dynamic molecular account of the shape of the learning curve, leads to several testable predictions regarding the link between epigenetic dynamics at the promoter, gene-network, and neural-network levels. This perspective opens up new avenues for therapeutic interventions in neurological pathologies.
منابع مشابه
Learning Curve Consideration in Makespan Computation Using Artificial Neural Network Approach
This paper presents an alternative method using artificial neural network (ANN) to develop a scheduling scheme which is used to determine the makespan or cycle time of a group of jobs going through a series of stages or workstations. The common conventional method uses mathematical programming techniques and presented in Gantt charts forms. The contribution of this paper is in three fold. First...
متن کاملINTEGRATED ADAPTIVE FUZZY CLUSTERING (IAFC) NEURAL NETWORKS USING FUZZY LEARNING RULES
The proposed IAFC neural networks have both stability and plasticity because theyuse a control structure similar to that of the ART-1(Adaptive Resonance Theory) neural network.The unsupervised IAFC neural network is the unsupervised neural network which uses the fuzzyleaky learning rule. This fuzzy leaky learning rule controls the updating amounts by fuzzymembership values. The supervised IAFC ...
متن کاملSORN: A Self-Organizing Recurrent Neural Network
Understanding the dynamics of recurrent neural networks is crucial for explaining how the brain processes information. In the neocortex, a range of different plasticity mechanisms are shaping recurrent networks into effective information processing circuits that learn appropriate representations for time-varying sensory stimuli. However, it has been difficult to mimic these abilities in artific...
متن کاملCritical neural networks with short and long term plasticity
In recent years self organised critical neuronal models have provided insights regarding the origin of the experimentally observed avalanching behaviour of neuronal systems. It has been shown that dynamical synapses, as a form of short-term plasticity, can cause critical neuronal dynamics. Whereas long-term plasticity, such as hebbian or activity dependent plasticity, have a crucial role in sha...
متن کاملThe role of epigenetic regulation in learning and memory.
The formation of long-term memory involves a series of molecular and cellular changes, including gene transcription, protein synthesis and synaptic plasticity dynamics. Some of these changes arise during learning and are subsequently retained throughout life. 'Epigenetic' regulation, which involves DNA methylation and histone modifications, plays a critical role in retaining long-term changes i...
متن کامل